Welcome to the Coleman Lindsley Lab
The Lindsley Lab brings together physicians and scientists who are driven to improve outcomes for patients with blood cancers. The central focus of the laboratory is on myeloid malignancies [such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)] and bone marrow failure syndromes. We use genomic technologies to study samples from patients with these diseases as a way to define pathways of disease initiation and progression, and to identify mutations that predict outcomes after various treatments. We use mouse and cell line models to dissect the mechanisms by which these gene mutations cause disease.