Click here to view all research publications from the Lindsley laboratory.
Lab publications
2024
CRISPR-based rapid molecular diagnostic tests for fusion-driven leukemias.
Vedula RS, Karp HQ, Koob J, Lim F, Garcia JS, Winer ES, Luskin MR, Ghiaur G, Kim AS, Beppu LW, Sala-Torra O, Radich JP, Gootenberg JS, Abudayyeh O, Zhang F, Lindsley RC.
Blood. 2024 Jul 8:blood.2023022908. doi: 10.1182/blood.2023022908. PMID: 38976877.
Molecular ontogeny underlies the benefit of adding venetoclax to hypomethylating agents in newly diagnosed AML patients.
Shimony S, Garcia JS, Keating J, Chen EC, Luskin MR, Stahl M, Neuberg DS, DeAngelo DJ, Stone RM, Lindsley RC.
Leukemia. 2024 Mar 27. doi: 10.1038/s41375-024-02230-w. PMID: 38538860.
Combination therapy with hypomethylating agents and venetoclax versus intensive induction chemotherapy in IDH1- or IDH2-mutant newly diagnosed acute myeloid leukemia-A multicenter cohort study.
Bewersdorf JP, Shimony S, Shallis RM, Liu Y, Berton G, Schaefer EJ, Zeidan AM, Goldberg A, Stein E, Marcucci G, Bystrom RP, Lindsley RC, Chen EC, Ramos J, Stein A, Pullarkat V, Aldoss I, DeAngelo DJ, Neuberg DS, Stone RM, Garciaz S, Ball B, Stahl M.
Am J Hematol. 2024 Aug;99(8):1640-1643. doi: 10.1002/ajh.27366. PMID: 38751104.
Intensive Induction Chemotherapy versus Hypomethylating Agents in Combination with Venetoclax in NPM1-mutant AML.
Bewersdorf JP, Shimony S, Shallis RM, Liu Y, Berton G, Schaefer EJ, Zeidan AM, Goldberg AD, Stein EM, Marcucci G, Bystrom R, Lindsley RC, Chen EC, Ramos Perez JM, Stein AS, Pullarkat VA, Aldoss I, DeAngelo DJ, Neuberg DS, Stone RM, Garciaz S, Ball BJ, Stahl M.
Blood Adv. 2024 Jun 28:bloodadvances.2024012858. doi: 10.1182/bloodadvances.2024012858. PMID: 38941537.
Prophylactic maintenance with venetoclax/azacitidine after reduced-intensity conditioning allogeneic transplant for high-risk MDS and AML.
Garcia JS, Kim HT, Murdock HM, Ansuinelli M, Brock J, Cutler CS, Gooptu M, Ho VT, Koreth J, Nikiforow S, Romee R, Shapiro R, DeAngelo DJ, Stone RM, Bat-Erdene D, Ryan J, Contreras ME, Fell G, Letai A, Ritz J, Lindsley RC, Soiffer RJ, Antin JH.
Blood Adv. 2024 Feb 27;8(4):978-990. doi: 10.1182/bloodadvances.2023012120. PMID: 38197938; PMCID: PMC10883823.
Hypomethylating agents plus venetoclax compared with intensive induction chemotherapy regimens in molecularly defined secondary AML.
Shimony S, Bewersdorf JP, Shallis RM, Liu Y, Schaefer EJ, Zeidan AM, Goldberg AD, Stein EM, Marcucci G, Lindsley RC, Chen EC, Ramos Perez J, Stein A, DeAngelo DJ, Neuberg DS, Stone RM, Ball B, Stahl M.
Leukemia. 2024 Feb 20. doi: 10.1038/s41375-024-02175-0. PMID: 38378841.
Clonal hematopoiesis in the setting of hematopoietic cell transplantation.
Gibson CJ, Lindsley RC, Gondek LP.
Semin Hematol. 2024 Feb 1:S0037-1963(24)00012-X. doi: 10.1053/j.seminhematol.2024.01.011. PMID: 38429201.
2023
Allogeneic Hematopoietic Cell Transplantation Improves Outcome in Myelodysplastic Syndrome Across High-Risk Genetic Subgroups: Genetic Analysis of the Blood and Marrow Transplant Clinical Trials Network 1102 Study.
Versluis J, Saber W, Tsai HK, Gibson CJ, Dillon LW, Mishra A, McGuirk J, Maziarz RT, Westervelt P, Hegde P, Mukherjee D, Martens MJ, Logan B, Horowitz M, Hourigan CS, Nakamura R, Cutler C, Lindsley RC; Blood and Marrow Transplant Clinical Trials Network.
J Clin Oncol. 2023 Aug 22:JCO2300866. doi: 10.1200/JCO.23.00866. PMID: 37607457.
Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths.
Cortés-López M, Chamely P, Hawkins AG, Stanley RF, Swett AD, Ganesan S, Mouhieddine TH, Dai X, Kluegel L, Chen C, Batta K, Furer N, Vedula RS, Beaulaurier J, Drong AW, Hickey S, Dusaj N, Mullokandov G, Stasiw AM, Su J, Chaligné R, Juul S, Harrington E, Knowles DA, Potenski CJ, Wiseman DH, Tanay A, Shlush L, Lindsley RC, Ghobrial IM, Taylor J, Abdel-Wahab O, Gaiti F, Landau DA.
Cell Stem Cell. 2023 Aug 9:S1934-5909(23)00257-6. doi: 10.1016/j.stem.2023.07.012. PMID: 37582363.
Prediction of risk for myeloid malignancy in clonal hematopoiesis
Weeks LD, Niroula A, Neuberg D, Wong W, Lindsley RC, Luskin M, Berliner N, Stone RM, DeAngelo DJ, Soiffer R, Uddin MM, Griffin G, Vlasschaert C, Gibson CJ, Jaiswal S, Bick AG, Malcovati L, Natarajan P, Ebert BL.
NEJM Evid. 2023 May;2(5):10.1056/evidoa2200310. doi: 10.1056/evidoa2200310. PMID: 37483562; PMCID: PMC10361696.
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.
Miller PG, Sperling AS, Mayerhofer C, McConkey M, Ellegast JM, Da Silva C, Cohen DN, Wang C, Sharda A, Yan N, Saha S, Schluter C, Schechter IA, Słabicki M, Sandoval B, Kahn J, Boettcher S, Gibson CJ, Scadden DT, Stegmaier K, Bhatt S, Lindsley RC, Ebert BL.
Blood. 2023 Aug 18:blood.2023020331. doi: 10.1182/blood.2023020331. PMID: 37595362.
Germline predisposition traits in allogeneic hematopoietic stem-cell transplantation for myelodysplastic syndromes: a survey-based study and position paper on behalf of the Chronic Malignancies Working Party of the EBMT.
Gurnari C, Robin M, Godley LA, Drozd-Sokołowska J, Włodarski MW, Raj K, Onida F, Worel N, Ciceri F, Carbacioglu S, Kenyon M, Aljurf M, Bonfim C, Makishima H, Niemeyer C, Fenaux P, Zebisch A, Hamad N, Chalandon Y, Hellström-Lindberg E, Voso MT, Mecucci C, Duarte FB, Sebert M, Sicre de Fontbrune F, Soulier J, Shimamura A, Lindsley RC, Maciejewski JP, Calado RT, Yakoub-Agha I, McLornan DP.
Lancet Haematol. 2023 Oct 25:S2352-3026(23)00265-X. doi: 10.1016/S2352-3026(23)00265-X. PMID: 37898151.
Optimization of Advanced Molecular Genetic Testing Utilization in Hematopathology: A Goldilocks Approach to Bone Marrow Testing.
AlJabban A, Paik H, Aster JC, Berliner N, Brouillard J, Brown JR, Burns KH, Castillo JJ, Card J, Dal Cin P, DeAngelo DJ, Dorfman DM, Ebert BL, Garcia JS, Jacobson CA, Lakhani H, Laubach JP, Ligon AH, Lindeman NI, Lindsley RC, Lovitch SB, Luskin MR, Morgan EA, Nowak A, Petrides A, Pinkus GS, Pozdnyakova O, Steensma DP, Stone RM, Weinberg OK, Winer ES, Kim AS.
JCO Oncol Pract. 2023 Sep 8:OP2300217. doi: 10.1200/OP.23.00217. PMID: 37683132.
Incidence and predictors of anthracycline-related left ventricular dysfunction in acute myeloid leukemia
Stahl M, Giblin G, Liu Y, Winer ES, Garcia JS, Chen E, Wadleigh M, Ling K, Lindsley RC, Shimony S, Copson K, Charles A, DeAngelo DJ, Stone RM, Nohria A, Luskin MR.
Leuk Res. 2023 Jul 12;132:107351. doi: 10.1016/j.leukres.2023.107351. PMID: 37451200.
Outlier Expression of Isoforms by Targeted or Total RNA Sequencing Identifies Clinically Significant Genomic Variants in Hematolymphoid Tumors
Tsai HK, Gogakos T, Lip V, Tsai JM, Li YD, Fisch AS, Weiss J, Yang W, Grimmett L, DiToro D, Schaefer EJ, Lindsley RC, Tran TH, Caron M, Langlois S, Sinnett D, Pikman Y, Nardi V, Kim AS, Silverman LB, Harris MH.
J Mol Diagn. 2023 Jul 5:S1525-1578(23)00135-6. doi: 10.1016/j.jmoldx.2023.06.007. PMID: 37419244.
FLT3-ITD does not predict inferior prognosis in acute myeloid leukemia patients age ≥60 years
Shimony S, Fell GG, Chen EC, Tsai HK, Wadleigh M, Winer ES, Garcia JS, Luskin MR, Stahl M, Neuberg DS, DeAngelo DJ, Lindsley RC, Stone RM.
Blood Adv. 2023 May 10:bloodadvances.2023009748. doi: 10.1182/bloodadvances.2023009748. PMID: 37163357.
Utility of targeted gene sequencing to differentiate myeloid malignancies from other cytopenic conditions
DeZern AE, Goll JB, Lindsley RC, Bejar R, Wilson SH, Hebert D, Deeg J, Zhang L, Gore S, Al Baghdadi T, Maciejewski J, Liu J, Padron E, Komrojki R, Saber W, Abel G, Kroft SH, Harrington A, Grimes T, Reed H, Fulton RS, DiFronzo NL, Gillis N, Sekeres MA, Walter MJ.
Blood Adv. 2023 Jul 25;7(14):3749-3759. doi: 10.1182/bloodadvances.2022008578. PMID: 36947201; PMCID: PMC10368770.
2022
BCOR and BCORL1 mutations drive epigenetic reprogramming and oncogenic signaling by unlinking PRC1.1 from target genes
Schaefer EJ, Wang HC, Karp HQ, Meyer CA, Cejas P, Gearhart MD, Adelman ER, Fares I, Apffel A, Lim K, Xie Y, Gibson CJ, Schenone M, Murdock HM, Wang EZ, Gondek LP, Carroll MP, Vedula RS, Winer ES, Garcia JS, Stone RM, Luskin MR, Carr SA, Long HW, Bardwell VJ, Figueroa ME, Lindsley RC
Blood Cancer Discovery, 2022 Mar 1;3(2):116-135. doi: 10.1158/2643-3230.BCD-21-0115. PMID: 35015684
Donor clonal hematopoiesis and recipient outcomes after transplantation
Gibson CJ, Kim HT, Zhao L, Murdock HM, Hambley B, Ogata A, Madero-Marroquin R, Wang Shiyu, Green L, Fleharty M, Dougan T, Cheng C, Blumenstiel B, Cibulskis C, Tsuji J, Duran M, Gocke CD, Antin JH, Nikiforow S, DeZern AE, Chen YB, Ho VT, Jones RJ, Lennon NJ, Walt DR, Ritz J, Soiffer RJ, Gondek LP, Lindsley RC
J Clin Oncol. 2022 Jan 10;40(2):189-201. doi: 10.1200/JCO.21.02286. PMID: 34793200.
Impact of diagnostic genetics on remission MRD and transplantation outcomes in older AML patients
Murdock HM, Kim HT, Denlinger N, Vachhani P, Hambley BC, Manning BS, Gier S, Cho C, Tsai HK, McCurdy SR, Ho VT, Koreth J, Soiffer RJ, Ritz J, Carroll MP, Vasu S, Perales MA, Wang ES, Gondek LP, Devine SM, Alyea EP, Lindsley RC*, Gibson CJ
Blood. 2022 Jun 16;139(24):3546-3557. doi: 10.1182/blood.2021014520. PMID: 35286378.
*corresponding author
Prediction of Life-threatening and Disabling Bleeding in Patients with Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy
Versluis J, Pandey M, Flamand Y, Haydu JE, Belizaire R, Faber MG, Vedula RS, Charles A, Copson KM, Shimony S, Rozental A, Bendapudi P, Wolach O, Griffiths EA, Thompson JE, Stone RM, DeAngelo DJ, Neuberg D, Luskin MR, Wang ES, Lindsley RC.
Blood Advances. 2022 Jan 26:bloodadvances.2021006166. doi: 10.1182/bloodadvances.2021006166. PMID: 35081257.
Allelic Complexity of KMT2A Partial Tandem Duplications in Acute Myeloid Leukemia and Myelodysplastic Syndromes
Tsai HK, Gibson CJ, Murdock HM, Davineni P, Harris MH, Wang ES, Gondek LP, Kim AS, Nardi V, Lindsley RC.
Blood Adv. 2022 May 18:bloodadvances.2022007613. doi: 10.1182/bloodadvances.2022007613. PMID: 35584376.
Genomic Profiling of a Randomized Trial of Interferon-α versus Hydroxyurea in MPN Reveals Mutation-Specific Responses.
Knudsen TA, Skov V, Stevenson KE, Werner L, Duke W, Laurore C, Gibson CJ, Nag A, Thorner AR, Wollison B, Hansen DL, Ellervik C, El Fassi D, de Stricker K, Ocias LF, Brabrand M, Bjerrum OW, Overgaard U, Frederiksen M, Kristensen T, Kruse T, Thomassen M, Mourits-Andersen T, Severinsen MT, Stentoft J, Starklint J, Neuberg D, Kjaer L, Larsen TS, Hasselbalch HC*, Lindsley RC*, Mullally A*.
Blood Adv. 2022 Apr 12;6(7):2107-2119. doi: 10.1182/bloodadvances.2021004856. PMID: 34507355.
*contributed equally
Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation.
Chen S, Vedula RS, Cuevas-Navarro A, Lu B, Hogg SJ, Wang E, Benbarche S, Knorr K, Kim WJ, Stanley RF, Cho H, Erickson C, Singer M, Cui D, Tittley S, Durham BH, Pavletich TS, Fiala E, Walsh MF, Inoue D, Monette S, Taylor J, Rosen N, McCormick F, Lindsley RC, Castel P, Abdel-Wahab O.
Cancer Discov. 2022 Jul 29:CD-21-1631. doi: 10.1158/2159-8290.CD-21-1631. PMID: 35904492.
Outcomes of antifungal prophylaxis for newly diagnosed AML patients treated with a hypomethylating agent and venetoclax.
Chen EC, Liu Y, Harris CE, Winer ES, Wadleigh M, Lane AA, Vedula RS, Lindsley RC, Copson KM, Charles A, Marty F, Neuberg D, DeAngelo DJ, Stone RM, Luskin MR, Issa NC, Garcia JS.
Leuk Lymphoma. 2022 Mar 15:1-8. doi: 10.1080/10428194.2022.2047964. PMID: 35289704.
Expansion, persistence, and efficacy of donor memory-like NK cells infused for post-transplant relapse.
Shapiro RM, Birch GC, Hu G, Vergara Cadavid J, Nikiforow S, Baginska J, Ali AK, Tarannum M, Sheffer M, Abdulhamid YZ, Rambaldi B, Arihara Y, Reynolds C, Halpern MS, Rodig SJ, Cullen N, Wolff JO, Pfaff KL, Lane AA, Lindsley RC, Cutler CS, Antin JH, Ho VT, Koreth J, Gooptu M, Kim HT, Malmberg KJ, Wu CJ, Chen J, Soiffer RJ, Ritz J, Romee R.
J Clin Invest. 2022 Jun 1;132(11):e154334. doi: 10.1172/JCI154334. PMID: 35349491; PMCID: PMC9151697.
Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine.
Gigoux M, Holmström MO, Zappasodi R, Park JJ, Pourpe S, Bozkus CC, Mangarin LMB, Redmond D, Verma S, Schad S, George MM, Venkatesh D, Ghosh A, Hoyos D, Molvi Z, Kamaz B, Marneth AE, Duke W, Leventhal MJ, Jan M, Ho VT, Hobbs GS, Knudsen TA, Skov V, Kjær L, Larsen TS, Hansen DL, Lindsley RC, Hasselbalch H, Grauslund JH, Lisle TL, Met Ö, Wilkinson P, Greenbaum B, Sepulveda MA, Chan T, Rampal R, Andersen MH, Abdel-Wahab O, Bhardwaj N, Wolchok JD, Mullally A, Merghoub T.
Sci Transl Med. 2022 Jun 15;14(649):eaba4380. doi: 10.1126/scitranslmed.aba4380. PMID: 35704596.
Germline predisposition variants occur in myelodysplastic syndrome patients of all ages.
Feurstein SK, Trottier AM, Estrada-Merly N, Pozsgai MJ, McNeely KE, Drazer MW, Ruhle B, Sadera K, Koppayi AL, Scott BL, Oran B, Nishihori T, Agrawal V, Saad A, Lindsley RC, Nakamura R, Kim S, Hu ZH, Sobecks RM, Spellman SR, Saber W, Godley LA.
Blood. 2022 Aug 19:blood.2022015790. doi: 10.1182/blood.2022015790. PMID: 35969835.
Transplant for TP53-mutated MDS and AML: because we can or because we should?
Versluis J, Lindsley RC.
Hematology Am Soc Hematol Educ Program. 2022 Dec 9;2022(1):522-527. doi: 10.1182/hematology.2022000354. PMID: 36485102.
2021
The clinical and functional effects of TERT variants in myelodysplastic syndrome
Reilly CR, Myllymäki M, Redd R, Padmanaban S, Karunakaran D, Tesmer T, Tsai FD, Gibson CJ, Rana HQ, Zhong L, Saber W, Spellman SR, Hu Z, Orr EH, Chen MM, De Vivo I, Cutler C, Antin JH, Neuberg D, Garber JE, Nandakumar J, Agarwal S, Lindsley RC
Blood. 2021 Sep 9;138(10):898-911. doi: 10.1182/blood.2021011075. PMID: 34019641.
Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome.
Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, Muscato GM, Klein RH, Ballotti K, Liu S, Harris CE, Galvin A, Malsch M, Dale D, Gansner JM, Nakano TA, Bertuch A, Vlachos A, Lipton JM, Castillo P, Connelly J, Churpek J, Edwards JR, Hijiya N, Ho RH, Hofmann I, Huang JN, Keel S, Lamble A, Lau BW, Norkin M, Stieglitz E, Stock W, Walkovich K, Boettcher S, Brendel C, Fleming MD, Davies SM, Weller EA, Bahl C, Carter SL, Shimamura A, Lindsley RC.
Nat Commun. 2021 Feb 26;12(1):1334. doi: 10.1038/s41467-021-21588-4. PMID: 33637765.
Somatic GATA2 mutations define a subgroup of myeloid malignancy patients at high risk for invasive fungal disease.
Vedula RS, Cheng MP, Ronayne CE, Farmakiotis D, Ho VT, Koo S, Marty FM, Lindsley RC*, Bold TD
Blood Adv. 2021 Jan 12;5(1):54-60. doi: 10.1182/bloodadvances.2020002854. PMID: 33570623; PMCID: PMC7805332.
*corresponding author
Modeling and targeting of erythroleukemia by hematopoietic genome editing.
Iacobucci I, Qu C, Varotto E, Janke LJ, Yang X, Seth A, Shelat A, Friske J, Fukano R, Yu J, Freeman BB, Kennedy JA, Sperling AS, Zheng R, Wang Y, Jogiraju H, Dickerson K, Payne-Turner DL, Morris SM, Hollis E, Ghosn NJ, Haggard GE, Lindsley RC, Ebert BL, Mullighan CG.
Blood. 2021 Jan 19:blood.2020009103. doi: 10.1182/blood.2020009103. PMID: 33512458.
Adding venetoclax to fludarabine/busulfan RIC transplant for high risk MDS and AML is feasible, safe, and active.
Garcia JS, Kim HT, Murdock HM, Cutler CS, Brock J, Gooptu M, Ho VT, Koreth J, Nikiforow S, Romee R, Shapiro RM, Loschi F, Ryan JA, Fell G, Karp HQ, Lucas F, Kim AS, Potter DS, Mashaka T, Stone RM, DeAngelo DJ, Letai A, Lindsley RC, Soiffer RJ, Antin JH.
Blood Adv. 2021 Dec 28;5(24):5536-5545. doi: 10.1182/bloodadvances.2021005566. PMID: 34614506; PMCID: PMC8714724.
Clonal hematopoiesis in sickle cell disease.
Pincez T, Lee SSK, Ilboudo Y, Preuss M, Pham Hung d'Alexandry d'Orengiani AL, Bartolucci P, Galactéros F, Joly P, Bauer DE, Loos RJF, Lindsley RC, Lettre G.
Blood. 2021 Nov 25;138(21):2148-2152. doi: 10.1182/blood.2021011121. PMID: 34521115; PMCID: PMC8617438.
Pretreatment clinical and genetic factors predict early post-treatment mortality in fit AML patients following induction.
Haydu JE, Flamand Y, Vedula RS, Versluis J, Charles A, Copson KM, Stone RM, DeAngelo DJ, Neuberg D, Lindsley RC, Luskin MR.
Am J Hematol. 2021 Apr 10. doi: 10.1002/ajh.26188. PMID: 33837971.
2020
Short telomere length predicts nonrelapse mortality after stem cell transplantation for myelodysplastic syndrome.
Myllymäki M, Redd R, Reilly CR, Saber W, Spellman SR, Gibson CJ, Hu ZH, Wang T, Orr EH, Grenier JG, Chen MM, Steensma DP, Cutler C, De Vivo I, Antin JH, Neuberg D, Agarwal S, Lindsley RC.
Blood. 2020 Dec 24;136(26):3070-3081. doi: 10.1182/blood.2020005397. PMID: 33367544; PMCID: PMC7770569.
Clonal hematopoiesis in the inherited bone marrow failure syndromes.
Tsai FD, Lindsley RC.
Blood. 2020 Oct 1;136(14):1615-1622. doi: 10.1182/blood.2019000990. PMID: 32736377; PMCID: PMC7530647.
A Personalized Prediction Model for Outcomes after Allogeneic Hematopoietic Cell Transplant in Patients with Myelodysplastic Syndromes.
Nazha A, Hu ZH, Wang T, Lindsley RC, Abdel-Azim H, Aljurf M, Bacher U, Bashey A, Cahn JY, Cerny J, Copelan E, DeFilipp Z, Diaz MA, Farhadfar N, Gadalla SM, Gale RP, George B, Gergis U, Grunwald MR, Hamilton B, Hashmi S, Hildebrandt GC, Inamoto Y, Kalaycio M, Kamble RT, Kharfan-Dabaja MA, Lazarus HM, Liesveld JL, Litzow MR, Majhail NS, Murthy HS, Nathan S, Nishihori T, Pawarode A, Rizzieri D, Sabloff M, Savani BN, Schachter L, Schouten HC, Seo S, Shah NN, Solh M, Valcárcel D, Vij R, Warlick E, Wirk B, Wood WA, Yared JA, Alyea E, Popat U, Sobecks RM, Scott BL, Nakamura R, Saber W.
Biol Blood Marrow Transplant. 2020 Nov;26(11):2139-2146. doi: 10.1016/j.bbmt.2020.08.003. PMID: 32781289; PMCID: PMC7609542.
Stem cell donors should not be screened for clonal hematopoiesis.
Gibson CJ, Lindsley RC.
Blood Adv. 2020 Feb 25;4(4):789-792. doi: 10.1182/bloodadvances.2019000395. PMID: 32097457; PMCID: PMC7042999.
Targeted Informatics for Optimal Detection, Characterization, and Quantification of FLT3 Internal Tandem Duplications Across Multiple Next- Generation Sequencing Platforms.
Tsai HK, Brackett DG, Szeto D, Frazier R, MacLeay A, Davineni P, Manning DK, Garcia E, Lindeman NI, Le LP, Lennerz JK, Gibson CJ, Lindsley RC, Kim AS, Nardi V.
J Mol Diagn. 2020 Sep;22(9):1162-1178. doi: 10.1016/j.jmoldx.2020.06.006. PMID: 32603763; PMCID: PMC7479488.
Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells.
Nagpal N, Wang J, Zeng J, Lo E, Moon DH, Luk K, Braun RO, Burroughs LM, Keel SB, Reilly C, Lindsley RC, Wolfe SA, Tai AK, Cahan P, Bauer DE, Fong YW, Agarwal S.
Cell Stem Cell. 2020 Jun 4;26(6):896-909.e8. doi: 10.1016/j.stem.2020.03.016. PMID: 32320679; PMCID: PMC7275922.
Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single- arm, phase 2 trial.
Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT.
Lancet Haematol. 2020 Feb;7(2):e122-e133. doi: 10.1016/S2352-3026(19)30203-0. PMID: 31837959.
2019
Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation.
Jan M, Leventhal MJ, Morgan EA, Wengrod JC, Nag A, Drinan SD, Wollison BM, Ducar MD, Thorner AR, Leppanen S, Baronas J, Stevens J, Lane WJ, Kekre N, Ho VT, Koreth J, Cutler CS, Nikiforow S, Alyea EP 3rd, Antin JH, Soiffer RJ, Ritz J, Lindsley RC*, Ebert BL*.
Blood Adv. 2019 Jul 23;3(14):2199-2204. doi: 10.1182/bloodadvances.2019000445. PubMed PMID: 31324640; PubMed Central PMCID: PMC6650729.
*co-corresponding authors
A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies.
Boettcher S, Miller PG, Sharma R, McConkey M, Leventhal M, Krivtsov AV, Giacomelli AO, Wong W, Kim J, Chao S, Kurppa KJ, Yang X, Milenkowic K, Piccioni F, Root DE, Rücker FG, Flamand Y, Neuberg D, Lindsley RC, Jänne PA, Hahn WC, Jacks T, Döhner H, Armstrong SA, Ebert BL.
Science. 2019 Aug 9;365(6453):599-604. doi: 10.1126/science.aax3649. PubMed PMID: 31395785; PubMed Central PMCID: PMC7327437.
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.
Adelman ER, Huang HT, Roisman A, Olsson A, Colaprico A, Qin T, Lindsley RC, Bejar R, Salomonis N, Grimes HL, Figueroa ME.
Cancer Discov. 2019 Aug;9(8):1080-1101. doi: 10.1158/2159-8290.CD-18-1474. PubMed PMID: 31085557; PubMed Central PMCID: PMC7080409.
Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background.
Yin M, Chung YJ, Lindsley RC, Walker RL, Zhu YJ, Ebert BL, Meltzer PS, Aplan PD.
Blood. 2019 Jun 13;133(24):2610-2614. doi: 10.1182/blood.2018864173. PubMed PMID: 30992267; PubMed Central PMCID: PMC6566592.
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG.
Nat Genet. 2019 Apr;51(4):694-704. doi: 10.1038/s41588-019-0375-1. PubMed PMID: 30926971; PubMed Central PMCID: PMC6828160.
2018
Significance of Clonal Mutations in Bone Marrow Failure and Inherited Myelodysplastic Syndrome/Acute Myeloid Leukemia Predisposition Syndromes.
Schaefer EJ, Lindsley RC.
Hematol Oncol Clin North Am. 2018 Aug;32(4):643-655. doi: 10.1016/j.hoc.2018.03.005. Review. PubMed PMID: 30047417; PubMed Central PMCID: PMC6065266.
2017
Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation.
Lindsley RC, Saber W, Mar BG, Redd R, Wang T, Haagenson MD, Grauman PV, Hu ZH, Spellman SR, Lee SJ, Verneris MR, Hsu K, Fleischhauer K, Cutler C, Antin JH, Neuberg D, Ebert BL.
N Engl J Med. 2017 Feb 9;376(6):536-547. doi: 10.1056/NEJMoa1611604. PubMed PMID: 28177873; PubMed Central PMCID: PMC5438571.
Donor-engrafted CHIP is common among stem cell transplant recipients with unexplained cytopenias.
Gibson CJ, Kennedy JA, Nikiforow S, Kuo FC, Alyea EP, Ho V, Ritz J, Soiffer R, Antin JH, Lindsley RC.
Blood. 2017 Jul 6;130(1):91-94. doi: 10.1182/blood-2017-01-764951. PubMed PMID: 28446434; PubMed Central PMCID: PMC5501150.
Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.
Gibson CJ, Lindsley RC, Tchekmedyian V, Mar BG, Shi J, Jaiswal S, Bosworth A, Francisco L, He J, Bansal A, Morgan EA, Lacasce AS, Freedman AS, Fisher DC, Jacobsen E, Armand P, Alyea EP, Koreth J, Ho V, Soiffer RJ, Antin JH, Ritz J, Nikiforow S, Forman SJ, Michor F, Neuberg D, Bhatia R, Bhatia S, Ebert BL.
J Clin Oncol. 2017 May 10;35(14):1598-1605. doi: 10.1200/JCO.2016.71.6712. PubMed PMID: 28068180; PubMed Central PMCID: PMC5455707.
Uncoding the genetic heterogeneity of myelodysplastic syndrome.
Lindsley RC.
Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):447-452. doi: 10.1182/asheducation-2017.1.447. Review. PubMed PMID: 29222292; PubMed Central PMCID: PMC6142603.
Measurement of Residual Disease in Acute Myeloid Leukemia.
Vedula RS, Lindsley RC.
Curr Hematol Malig Rep. 2017 Dec;12(6):574-581. doi: 10.1007/s11899-017-0428-4. Review. PubMed PMID: 29064024; NIHMSID:NIHMS1592442.
Mutational complexity in myelodysplasia.
Lindsley RC.
Best Pract Res Clin Haematol. 2017 Dec;30(4):290-294. doi: 10.1016/j.beha.2017.10.003. Review. PubMed PMID: 29156197.
Systematic STAT3 sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia.
Morgan EA, Lee MN, DeAngelo DJ, Steensma DP, Stone RM, Kuo FC, Aster JC, Gibson CJ, Lindsley RC.
Blood Adv. 2017 Sep 26;1(21):1786-1789. doi: 10.1182/bloodadvances.2017011197. PubMed PMID: 29296824; PubMed Central PMCID: PMC5728102.
The relative utilities of genome-wide, gene panel, and individual gene sequencing in clinical practice.
Kuo FC, Mar BG, Lindsley RC, Lindeman NI.
Blood. 2017 Jul 27;130(4):433-439. doi: 10.1182/blood-2017-03-734533. Review. PubMed PMID: 28600338; PubMed Central PMCID: PMC5813726.
CRISPR-based rapid molecular diagnostic tests for fusion-driven leukemias.
Vedula RS, Karp HQ, Koob J, Lim F, Garcia JS, Winer ES, Luskin MR, Ghiaur G, Kim AS, Beppu LW, Sala-Torra O, Radich JP, Gootenberg JS, Abudayyeh O, Zhang F, Lindsley RC.
Blood. 2024 Jul 8:blood.2023022908. doi: 10.1182/blood.2023022908. PMID: 38976877.
Molecular ontogeny underlies the benefit of adding venetoclax to hypomethylating agents in newly diagnosed AML patients.
Shimony S, Garcia JS, Keating J, Chen EC, Luskin MR, Stahl M, Neuberg DS, DeAngelo DJ, Stone RM, Lindsley RC.
Leukemia. 2024 Mar 27. doi: 10.1038/s41375-024-02230-w. PMID: 38538860.
Combination therapy with hypomethylating agents and venetoclax versus intensive induction chemotherapy in IDH1- or IDH2-mutant newly diagnosed acute myeloid leukemia-A multicenter cohort study.
Bewersdorf JP, Shimony S, Shallis RM, Liu Y, Berton G, Schaefer EJ, Zeidan AM, Goldberg A, Stein E, Marcucci G, Bystrom RP, Lindsley RC, Chen EC, Ramos J, Stein A, Pullarkat V, Aldoss I, DeAngelo DJ, Neuberg DS, Stone RM, Garciaz S, Ball B, Stahl M.
Am J Hematol. 2024 Aug;99(8):1640-1643. doi: 10.1002/ajh.27366. PMID: 38751104.
Intensive Induction Chemotherapy versus Hypomethylating Agents in Combination with Venetoclax in NPM1-mutant AML.
Bewersdorf JP, Shimony S, Shallis RM, Liu Y, Berton G, Schaefer EJ, Zeidan AM, Goldberg AD, Stein EM, Marcucci G, Bystrom R, Lindsley RC, Chen EC, Ramos Perez JM, Stein AS, Pullarkat VA, Aldoss I, DeAngelo DJ, Neuberg DS, Stone RM, Garciaz S, Ball BJ, Stahl M.
Blood Adv. 2024 Jun 28:bloodadvances.2024012858. doi: 10.1182/bloodadvances.2024012858. PMID: 38941537.
Prophylactic maintenance with venetoclax/azacitidine after reduced-intensity conditioning allogeneic transplant for high-risk MDS and AML.
Garcia JS, Kim HT, Murdock HM, Ansuinelli M, Brock J, Cutler CS, Gooptu M, Ho VT, Koreth J, Nikiforow S, Romee R, Shapiro R, DeAngelo DJ, Stone RM, Bat-Erdene D, Ryan J, Contreras ME, Fell G, Letai A, Ritz J, Lindsley RC, Soiffer RJ, Antin JH.
Blood Adv. 2024 Feb 27;8(4):978-990. doi: 10.1182/bloodadvances.2023012120. PMID: 38197938; PMCID: PMC10883823.
Hypomethylating agents plus venetoclax compared with intensive induction chemotherapy regimens in molecularly defined secondary AML.
Shimony S, Bewersdorf JP, Shallis RM, Liu Y, Schaefer EJ, Zeidan AM, Goldberg AD, Stein EM, Marcucci G, Lindsley RC, Chen EC, Ramos Perez J, Stein A, DeAngelo DJ, Neuberg DS, Stone RM, Ball B, Stahl M.
Leukemia. 2024 Feb 20. doi: 10.1038/s41375-024-02175-0. PMID: 38378841.
Clonal hematopoiesis in the setting of hematopoietic cell transplantation.
Gibson CJ, Lindsley RC, Gondek LP.
Semin Hematol. 2024 Feb 1:S0037-1963(24)00012-X. doi: 10.1053/j.seminhematol.2024.01.011. PMID: 38429201.
2023
Allogeneic Hematopoietic Cell Transplantation Improves Outcome in Myelodysplastic Syndrome Across High-Risk Genetic Subgroups: Genetic Analysis of the Blood and Marrow Transplant Clinical Trials Network 1102 Study.
Versluis J, Saber W, Tsai HK, Gibson CJ, Dillon LW, Mishra A, McGuirk J, Maziarz RT, Westervelt P, Hegde P, Mukherjee D, Martens MJ, Logan B, Horowitz M, Hourigan CS, Nakamura R, Cutler C, Lindsley RC; Blood and Marrow Transplant Clinical Trials Network.
J Clin Oncol. 2023 Aug 22:JCO2300866. doi: 10.1200/JCO.23.00866. PMID: 37607457.
Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths.
Cortés-López M, Chamely P, Hawkins AG, Stanley RF, Swett AD, Ganesan S, Mouhieddine TH, Dai X, Kluegel L, Chen C, Batta K, Furer N, Vedula RS, Beaulaurier J, Drong AW, Hickey S, Dusaj N, Mullokandov G, Stasiw AM, Su J, Chaligné R, Juul S, Harrington E, Knowles DA, Potenski CJ, Wiseman DH, Tanay A, Shlush L, Lindsley RC, Ghobrial IM, Taylor J, Abdel-Wahab O, Gaiti F, Landau DA.
Cell Stem Cell. 2023 Aug 9:S1934-5909(23)00257-6. doi: 10.1016/j.stem.2023.07.012. PMID: 37582363.
Prediction of risk for myeloid malignancy in clonal hematopoiesis
Weeks LD, Niroula A, Neuberg D, Wong W, Lindsley RC, Luskin M, Berliner N, Stone RM, DeAngelo DJ, Soiffer R, Uddin MM, Griffin G, Vlasschaert C, Gibson CJ, Jaiswal S, Bick AG, Malcovati L, Natarajan P, Ebert BL.
NEJM Evid. 2023 May;2(5):10.1056/evidoa2200310. doi: 10.1056/evidoa2200310. PMID: 37483562; PMCID: PMC10361696.
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.
Miller PG, Sperling AS, Mayerhofer C, McConkey M, Ellegast JM, Da Silva C, Cohen DN, Wang C, Sharda A, Yan N, Saha S, Schluter C, Schechter IA, Słabicki M, Sandoval B, Kahn J, Boettcher S, Gibson CJ, Scadden DT, Stegmaier K, Bhatt S, Lindsley RC, Ebert BL.
Blood. 2023 Aug 18:blood.2023020331. doi: 10.1182/blood.2023020331. PMID: 37595362.
Germline predisposition traits in allogeneic hematopoietic stem-cell transplantation for myelodysplastic syndromes: a survey-based study and position paper on behalf of the Chronic Malignancies Working Party of the EBMT.
Gurnari C, Robin M, Godley LA, Drozd-Sokołowska J, Włodarski MW, Raj K, Onida F, Worel N, Ciceri F, Carbacioglu S, Kenyon M, Aljurf M, Bonfim C, Makishima H, Niemeyer C, Fenaux P, Zebisch A, Hamad N, Chalandon Y, Hellström-Lindberg E, Voso MT, Mecucci C, Duarte FB, Sebert M, Sicre de Fontbrune F, Soulier J, Shimamura A, Lindsley RC, Maciejewski JP, Calado RT, Yakoub-Agha I, McLornan DP.
Lancet Haematol. 2023 Oct 25:S2352-3026(23)00265-X. doi: 10.1016/S2352-3026(23)00265-X. PMID: 37898151.
Optimization of Advanced Molecular Genetic Testing Utilization in Hematopathology: A Goldilocks Approach to Bone Marrow Testing.
AlJabban A, Paik H, Aster JC, Berliner N, Brouillard J, Brown JR, Burns KH, Castillo JJ, Card J, Dal Cin P, DeAngelo DJ, Dorfman DM, Ebert BL, Garcia JS, Jacobson CA, Lakhani H, Laubach JP, Ligon AH, Lindeman NI, Lindsley RC, Lovitch SB, Luskin MR, Morgan EA, Nowak A, Petrides A, Pinkus GS, Pozdnyakova O, Steensma DP, Stone RM, Weinberg OK, Winer ES, Kim AS.
JCO Oncol Pract. 2023 Sep 8:OP2300217. doi: 10.1200/OP.23.00217. PMID: 37683132.
Incidence and predictors of anthracycline-related left ventricular dysfunction in acute myeloid leukemia
Stahl M, Giblin G, Liu Y, Winer ES, Garcia JS, Chen E, Wadleigh M, Ling K, Lindsley RC, Shimony S, Copson K, Charles A, DeAngelo DJ, Stone RM, Nohria A, Luskin MR.
Leuk Res. 2023 Jul 12;132:107351. doi: 10.1016/j.leukres.2023.107351. PMID: 37451200.
Outlier Expression of Isoforms by Targeted or Total RNA Sequencing Identifies Clinically Significant Genomic Variants in Hematolymphoid Tumors
Tsai HK, Gogakos T, Lip V, Tsai JM, Li YD, Fisch AS, Weiss J, Yang W, Grimmett L, DiToro D, Schaefer EJ, Lindsley RC, Tran TH, Caron M, Langlois S, Sinnett D, Pikman Y, Nardi V, Kim AS, Silverman LB, Harris MH.
J Mol Diagn. 2023 Jul 5:S1525-1578(23)00135-6. doi: 10.1016/j.jmoldx.2023.06.007. PMID: 37419244.
FLT3-ITD does not predict inferior prognosis in acute myeloid leukemia patients age ≥60 years
Shimony S, Fell GG, Chen EC, Tsai HK, Wadleigh M, Winer ES, Garcia JS, Luskin MR, Stahl M, Neuberg DS, DeAngelo DJ, Lindsley RC, Stone RM.
Blood Adv. 2023 May 10:bloodadvances.2023009748. doi: 10.1182/bloodadvances.2023009748. PMID: 37163357.
Utility of targeted gene sequencing to differentiate myeloid malignancies from other cytopenic conditions
DeZern AE, Goll JB, Lindsley RC, Bejar R, Wilson SH, Hebert D, Deeg J, Zhang L, Gore S, Al Baghdadi T, Maciejewski J, Liu J, Padron E, Komrojki R, Saber W, Abel G, Kroft SH, Harrington A, Grimes T, Reed H, Fulton RS, DiFronzo NL, Gillis N, Sekeres MA, Walter MJ.
Blood Adv. 2023 Jul 25;7(14):3749-3759. doi: 10.1182/bloodadvances.2022008578. PMID: 36947201; PMCID: PMC10368770.
2022
BCOR and BCORL1 mutations drive epigenetic reprogramming and oncogenic signaling by unlinking PRC1.1 from target genes
Schaefer EJ, Wang HC, Karp HQ, Meyer CA, Cejas P, Gearhart MD, Adelman ER, Fares I, Apffel A, Lim K, Xie Y, Gibson CJ, Schenone M, Murdock HM, Wang EZ, Gondek LP, Carroll MP, Vedula RS, Winer ES, Garcia JS, Stone RM, Luskin MR, Carr SA, Long HW, Bardwell VJ, Figueroa ME, Lindsley RC
Blood Cancer Discovery, 2022 Mar 1;3(2):116-135. doi: 10.1158/2643-3230.BCD-21-0115. PMID: 35015684
Donor clonal hematopoiesis and recipient outcomes after transplantation
Gibson CJ, Kim HT, Zhao L, Murdock HM, Hambley B, Ogata A, Madero-Marroquin R, Wang Shiyu, Green L, Fleharty M, Dougan T, Cheng C, Blumenstiel B, Cibulskis C, Tsuji J, Duran M, Gocke CD, Antin JH, Nikiforow S, DeZern AE, Chen YB, Ho VT, Jones RJ, Lennon NJ, Walt DR, Ritz J, Soiffer RJ, Gondek LP, Lindsley RC
J Clin Oncol. 2022 Jan 10;40(2):189-201. doi: 10.1200/JCO.21.02286. PMID: 34793200.
Impact of diagnostic genetics on remission MRD and transplantation outcomes in older AML patients
Murdock HM, Kim HT, Denlinger N, Vachhani P, Hambley BC, Manning BS, Gier S, Cho C, Tsai HK, McCurdy SR, Ho VT, Koreth J, Soiffer RJ, Ritz J, Carroll MP, Vasu S, Perales MA, Wang ES, Gondek LP, Devine SM, Alyea EP, Lindsley RC*, Gibson CJ
Blood. 2022 Jun 16;139(24):3546-3557. doi: 10.1182/blood.2021014520. PMID: 35286378.
*corresponding author
Prediction of Life-threatening and Disabling Bleeding in Patients with Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy
Versluis J, Pandey M, Flamand Y, Haydu JE, Belizaire R, Faber MG, Vedula RS, Charles A, Copson KM, Shimony S, Rozental A, Bendapudi P, Wolach O, Griffiths EA, Thompson JE, Stone RM, DeAngelo DJ, Neuberg D, Luskin MR, Wang ES, Lindsley RC.
Blood Advances. 2022 Jan 26:bloodadvances.2021006166. doi: 10.1182/bloodadvances.2021006166. PMID: 35081257.
Allelic Complexity of KMT2A Partial Tandem Duplications in Acute Myeloid Leukemia and Myelodysplastic Syndromes
Tsai HK, Gibson CJ, Murdock HM, Davineni P, Harris MH, Wang ES, Gondek LP, Kim AS, Nardi V, Lindsley RC.
Blood Adv. 2022 May 18:bloodadvances.2022007613. doi: 10.1182/bloodadvances.2022007613. PMID: 35584376.
Genomic Profiling of a Randomized Trial of Interferon-α versus Hydroxyurea in MPN Reveals Mutation-Specific Responses.
Knudsen TA, Skov V, Stevenson KE, Werner L, Duke W, Laurore C, Gibson CJ, Nag A, Thorner AR, Wollison B, Hansen DL, Ellervik C, El Fassi D, de Stricker K, Ocias LF, Brabrand M, Bjerrum OW, Overgaard U, Frederiksen M, Kristensen T, Kruse T, Thomassen M, Mourits-Andersen T, Severinsen MT, Stentoft J, Starklint J, Neuberg D, Kjaer L, Larsen TS, Hasselbalch HC*, Lindsley RC*, Mullally A*.
Blood Adv. 2022 Apr 12;6(7):2107-2119. doi: 10.1182/bloodadvances.2021004856. PMID: 34507355.
*contributed equally
Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation.
Chen S, Vedula RS, Cuevas-Navarro A, Lu B, Hogg SJ, Wang E, Benbarche S, Knorr K, Kim WJ, Stanley RF, Cho H, Erickson C, Singer M, Cui D, Tittley S, Durham BH, Pavletich TS, Fiala E, Walsh MF, Inoue D, Monette S, Taylor J, Rosen N, McCormick F, Lindsley RC, Castel P, Abdel-Wahab O.
Cancer Discov. 2022 Jul 29:CD-21-1631. doi: 10.1158/2159-8290.CD-21-1631. PMID: 35904492.
Outcomes of antifungal prophylaxis for newly diagnosed AML patients treated with a hypomethylating agent and venetoclax.
Chen EC, Liu Y, Harris CE, Winer ES, Wadleigh M, Lane AA, Vedula RS, Lindsley RC, Copson KM, Charles A, Marty F, Neuberg D, DeAngelo DJ, Stone RM, Luskin MR, Issa NC, Garcia JS.
Leuk Lymphoma. 2022 Mar 15:1-8. doi: 10.1080/10428194.2022.2047964. PMID: 35289704.
Expansion, persistence, and efficacy of donor memory-like NK cells infused for post-transplant relapse.
Shapiro RM, Birch GC, Hu G, Vergara Cadavid J, Nikiforow S, Baginska J, Ali AK, Tarannum M, Sheffer M, Abdulhamid YZ, Rambaldi B, Arihara Y, Reynolds C, Halpern MS, Rodig SJ, Cullen N, Wolff JO, Pfaff KL, Lane AA, Lindsley RC, Cutler CS, Antin JH, Ho VT, Koreth J, Gooptu M, Kim HT, Malmberg KJ, Wu CJ, Chen J, Soiffer RJ, Ritz J, Romee R.
J Clin Invest. 2022 Jun 1;132(11):e154334. doi: 10.1172/JCI154334. PMID: 35349491; PMCID: PMC9151697.
Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine.
Gigoux M, Holmström MO, Zappasodi R, Park JJ, Pourpe S, Bozkus CC, Mangarin LMB, Redmond D, Verma S, Schad S, George MM, Venkatesh D, Ghosh A, Hoyos D, Molvi Z, Kamaz B, Marneth AE, Duke W, Leventhal MJ, Jan M, Ho VT, Hobbs GS, Knudsen TA, Skov V, Kjær L, Larsen TS, Hansen DL, Lindsley RC, Hasselbalch H, Grauslund JH, Lisle TL, Met Ö, Wilkinson P, Greenbaum B, Sepulveda MA, Chan T, Rampal R, Andersen MH, Abdel-Wahab O, Bhardwaj N, Wolchok JD, Mullally A, Merghoub T.
Sci Transl Med. 2022 Jun 15;14(649):eaba4380. doi: 10.1126/scitranslmed.aba4380. PMID: 35704596.
Germline predisposition variants occur in myelodysplastic syndrome patients of all ages.
Feurstein SK, Trottier AM, Estrada-Merly N, Pozsgai MJ, McNeely KE, Drazer MW, Ruhle B, Sadera K, Koppayi AL, Scott BL, Oran B, Nishihori T, Agrawal V, Saad A, Lindsley RC, Nakamura R, Kim S, Hu ZH, Sobecks RM, Spellman SR, Saber W, Godley LA.
Blood. 2022 Aug 19:blood.2022015790. doi: 10.1182/blood.2022015790. PMID: 35969835.
Transplant for TP53-mutated MDS and AML: because we can or because we should?
Versluis J, Lindsley RC.
Hematology Am Soc Hematol Educ Program. 2022 Dec 9;2022(1):522-527. doi: 10.1182/hematology.2022000354. PMID: 36485102.
2021
The clinical and functional effects of TERT variants in myelodysplastic syndrome
Reilly CR, Myllymäki M, Redd R, Padmanaban S, Karunakaran D, Tesmer T, Tsai FD, Gibson CJ, Rana HQ, Zhong L, Saber W, Spellman SR, Hu Z, Orr EH, Chen MM, De Vivo I, Cutler C, Antin JH, Neuberg D, Garber JE, Nandakumar J, Agarwal S, Lindsley RC
Blood. 2021 Sep 9;138(10):898-911. doi: 10.1182/blood.2021011075. PMID: 34019641.
Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome.
Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, Muscato GM, Klein RH, Ballotti K, Liu S, Harris CE, Galvin A, Malsch M, Dale D, Gansner JM, Nakano TA, Bertuch A, Vlachos A, Lipton JM, Castillo P, Connelly J, Churpek J, Edwards JR, Hijiya N, Ho RH, Hofmann I, Huang JN, Keel S, Lamble A, Lau BW, Norkin M, Stieglitz E, Stock W, Walkovich K, Boettcher S, Brendel C, Fleming MD, Davies SM, Weller EA, Bahl C, Carter SL, Shimamura A, Lindsley RC.
Nat Commun. 2021 Feb 26;12(1):1334. doi: 10.1038/s41467-021-21588-4. PMID: 33637765.
Somatic GATA2 mutations define a subgroup of myeloid malignancy patients at high risk for invasive fungal disease.
Vedula RS, Cheng MP, Ronayne CE, Farmakiotis D, Ho VT, Koo S, Marty FM, Lindsley RC*, Bold TD
Blood Adv. 2021 Jan 12;5(1):54-60. doi: 10.1182/bloodadvances.2020002854. PMID: 33570623; PMCID: PMC7805332.
*corresponding author
Modeling and targeting of erythroleukemia by hematopoietic genome editing.
Iacobucci I, Qu C, Varotto E, Janke LJ, Yang X, Seth A, Shelat A, Friske J, Fukano R, Yu J, Freeman BB, Kennedy JA, Sperling AS, Zheng R, Wang Y, Jogiraju H, Dickerson K, Payne-Turner DL, Morris SM, Hollis E, Ghosn NJ, Haggard GE, Lindsley RC, Ebert BL, Mullighan CG.
Blood. 2021 Jan 19:blood.2020009103. doi: 10.1182/blood.2020009103. PMID: 33512458.
Adding venetoclax to fludarabine/busulfan RIC transplant for high risk MDS and AML is feasible, safe, and active.
Garcia JS, Kim HT, Murdock HM, Cutler CS, Brock J, Gooptu M, Ho VT, Koreth J, Nikiforow S, Romee R, Shapiro RM, Loschi F, Ryan JA, Fell G, Karp HQ, Lucas F, Kim AS, Potter DS, Mashaka T, Stone RM, DeAngelo DJ, Letai A, Lindsley RC, Soiffer RJ, Antin JH.
Blood Adv. 2021 Dec 28;5(24):5536-5545. doi: 10.1182/bloodadvances.2021005566. PMID: 34614506; PMCID: PMC8714724.
Clonal hematopoiesis in sickle cell disease.
Pincez T, Lee SSK, Ilboudo Y, Preuss M, Pham Hung d'Alexandry d'Orengiani AL, Bartolucci P, Galactéros F, Joly P, Bauer DE, Loos RJF, Lindsley RC, Lettre G.
Blood. 2021 Nov 25;138(21):2148-2152. doi: 10.1182/blood.2021011121. PMID: 34521115; PMCID: PMC8617438.
Pretreatment clinical and genetic factors predict early post-treatment mortality in fit AML patients following induction.
Haydu JE, Flamand Y, Vedula RS, Versluis J, Charles A, Copson KM, Stone RM, DeAngelo DJ, Neuberg D, Lindsley RC, Luskin MR.
Am J Hematol. 2021 Apr 10. doi: 10.1002/ajh.26188. PMID: 33837971.
2020
Short telomere length predicts nonrelapse mortality after stem cell transplantation for myelodysplastic syndrome.
Myllymäki M, Redd R, Reilly CR, Saber W, Spellman SR, Gibson CJ, Hu ZH, Wang T, Orr EH, Grenier JG, Chen MM, Steensma DP, Cutler C, De Vivo I, Antin JH, Neuberg D, Agarwal S, Lindsley RC.
Blood. 2020 Dec 24;136(26):3070-3081. doi: 10.1182/blood.2020005397. PMID: 33367544; PMCID: PMC7770569.
- Commentary: Telomere length in hematopoietic cell transplant
Clonal hematopoiesis in the inherited bone marrow failure syndromes.
Tsai FD, Lindsley RC.
Blood. 2020 Oct 1;136(14):1615-1622. doi: 10.1182/blood.2019000990. PMID: 32736377; PMCID: PMC7530647.
A Personalized Prediction Model for Outcomes after Allogeneic Hematopoietic Cell Transplant in Patients with Myelodysplastic Syndromes.
Nazha A, Hu ZH, Wang T, Lindsley RC, Abdel-Azim H, Aljurf M, Bacher U, Bashey A, Cahn JY, Cerny J, Copelan E, DeFilipp Z, Diaz MA, Farhadfar N, Gadalla SM, Gale RP, George B, Gergis U, Grunwald MR, Hamilton B, Hashmi S, Hildebrandt GC, Inamoto Y, Kalaycio M, Kamble RT, Kharfan-Dabaja MA, Lazarus HM, Liesveld JL, Litzow MR, Majhail NS, Murthy HS, Nathan S, Nishihori T, Pawarode A, Rizzieri D, Sabloff M, Savani BN, Schachter L, Schouten HC, Seo S, Shah NN, Solh M, Valcárcel D, Vij R, Warlick E, Wirk B, Wood WA, Yared JA, Alyea E, Popat U, Sobecks RM, Scott BL, Nakamura R, Saber W.
Biol Blood Marrow Transplant. 2020 Nov;26(11):2139-2146. doi: 10.1016/j.bbmt.2020.08.003. PMID: 32781289; PMCID: PMC7609542.
Stem cell donors should not be screened for clonal hematopoiesis.
Gibson CJ, Lindsley RC.
Blood Adv. 2020 Feb 25;4(4):789-792. doi: 10.1182/bloodadvances.2019000395. PMID: 32097457; PMCID: PMC7042999.
Targeted Informatics for Optimal Detection, Characterization, and Quantification of FLT3 Internal Tandem Duplications Across Multiple Next- Generation Sequencing Platforms.
Tsai HK, Brackett DG, Szeto D, Frazier R, MacLeay A, Davineni P, Manning DK, Garcia E, Lindeman NI, Le LP, Lennerz JK, Gibson CJ, Lindsley RC, Kim AS, Nardi V.
J Mol Diagn. 2020 Sep;22(9):1162-1178. doi: 10.1016/j.jmoldx.2020.06.006. PMID: 32603763; PMCID: PMC7479488.
Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells.
Nagpal N, Wang J, Zeng J, Lo E, Moon DH, Luk K, Braun RO, Burroughs LM, Keel SB, Reilly C, Lindsley RC, Wolfe SA, Tai AK, Cahan P, Bauer DE, Fong YW, Agarwal S.
Cell Stem Cell. 2020 Jun 4;26(6):896-909.e8. doi: 10.1016/j.stem.2020.03.016. PMID: 32320679; PMCID: PMC7275922.
Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single- arm, phase 2 trial.
Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT.
Lancet Haematol. 2020 Feb;7(2):e122-e133. doi: 10.1016/S2352-3026(19)30203-0. PMID: 31837959.
2019
Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation.
Jan M, Leventhal MJ, Morgan EA, Wengrod JC, Nag A, Drinan SD, Wollison BM, Ducar MD, Thorner AR, Leppanen S, Baronas J, Stevens J, Lane WJ, Kekre N, Ho VT, Koreth J, Cutler CS, Nikiforow S, Alyea EP 3rd, Antin JH, Soiffer RJ, Ritz J, Lindsley RC*, Ebert BL*.
Blood Adv. 2019 Jul 23;3(14):2199-2204. doi: 10.1182/bloodadvances.2019000445. PubMed PMID: 31324640; PubMed Central PMCID: PMC6650729.
*co-corresponding authors
A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies.
Boettcher S, Miller PG, Sharma R, McConkey M, Leventhal M, Krivtsov AV, Giacomelli AO, Wong W, Kim J, Chao S, Kurppa KJ, Yang X, Milenkowic K, Piccioni F, Root DE, Rücker FG, Flamand Y, Neuberg D, Lindsley RC, Jänne PA, Hahn WC, Jacks T, Döhner H, Armstrong SA, Ebert BL.
Science. 2019 Aug 9;365(6453):599-604. doi: 10.1126/science.aax3649. PubMed PMID: 31395785; PubMed Central PMCID: PMC7327437.
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.
Adelman ER, Huang HT, Roisman A, Olsson A, Colaprico A, Qin T, Lindsley RC, Bejar R, Salomonis N, Grimes HL, Figueroa ME.
Cancer Discov. 2019 Aug;9(8):1080-1101. doi: 10.1158/2159-8290.CD-18-1474. PubMed PMID: 31085557; PubMed Central PMCID: PMC7080409.
Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background.
Yin M, Chung YJ, Lindsley RC, Walker RL, Zhu YJ, Ebert BL, Meltzer PS, Aplan PD.
Blood. 2019 Jun 13;133(24):2610-2614. doi: 10.1182/blood.2018864173. PubMed PMID: 30992267; PubMed Central PMCID: PMC6566592.
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG.
Nat Genet. 2019 Apr;51(4):694-704. doi: 10.1038/s41588-019-0375-1. PubMed PMID: 30926971; PubMed Central PMCID: PMC6828160.
2018
Significance of Clonal Mutations in Bone Marrow Failure and Inherited Myelodysplastic Syndrome/Acute Myeloid Leukemia Predisposition Syndromes.
Schaefer EJ, Lindsley RC.
Hematol Oncol Clin North Am. 2018 Aug;32(4):643-655. doi: 10.1016/j.hoc.2018.03.005. Review. PubMed PMID: 30047417; PubMed Central PMCID: PMC6065266.
2017
Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation.
Lindsley RC, Saber W, Mar BG, Redd R, Wang T, Haagenson MD, Grauman PV, Hu ZH, Spellman SR, Lee SJ, Verneris MR, Hsu K, Fleischhauer K, Cutler C, Antin JH, Neuberg D, Ebert BL.
N Engl J Med. 2017 Feb 9;376(6):536-547. doi: 10.1056/NEJMoa1611604. PubMed PMID: 28177873; PubMed Central PMCID: PMC5438571.
Donor-engrafted CHIP is common among stem cell transplant recipients with unexplained cytopenias.
Gibson CJ, Kennedy JA, Nikiforow S, Kuo FC, Alyea EP, Ho V, Ritz J, Soiffer R, Antin JH, Lindsley RC.
Blood. 2017 Jul 6;130(1):91-94. doi: 10.1182/blood-2017-01-764951. PubMed PMID: 28446434; PubMed Central PMCID: PMC5501150.
Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.
Gibson CJ, Lindsley RC, Tchekmedyian V, Mar BG, Shi J, Jaiswal S, Bosworth A, Francisco L, He J, Bansal A, Morgan EA, Lacasce AS, Freedman AS, Fisher DC, Jacobsen E, Armand P, Alyea EP, Koreth J, Ho V, Soiffer RJ, Antin JH, Ritz J, Nikiforow S, Forman SJ, Michor F, Neuberg D, Bhatia R, Bhatia S, Ebert BL.
J Clin Oncol. 2017 May 10;35(14):1598-1605. doi: 10.1200/JCO.2016.71.6712. PubMed PMID: 28068180; PubMed Central PMCID: PMC5455707.
Uncoding the genetic heterogeneity of myelodysplastic syndrome.
Lindsley RC.
Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):447-452. doi: 10.1182/asheducation-2017.1.447. Review. PubMed PMID: 29222292; PubMed Central PMCID: PMC6142603.
Measurement of Residual Disease in Acute Myeloid Leukemia.
Vedula RS, Lindsley RC.
Curr Hematol Malig Rep. 2017 Dec;12(6):574-581. doi: 10.1007/s11899-017-0428-4. Review. PubMed PMID: 29064024; NIHMSID:NIHMS1592442.
Mutational complexity in myelodysplasia.
Lindsley RC.
Best Pract Res Clin Haematol. 2017 Dec;30(4):290-294. doi: 10.1016/j.beha.2017.10.003. Review. PubMed PMID: 29156197.
Systematic STAT3 sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia.
Morgan EA, Lee MN, DeAngelo DJ, Steensma DP, Stone RM, Kuo FC, Aster JC, Gibson CJ, Lindsley RC.
Blood Adv. 2017 Sep 26;1(21):1786-1789. doi: 10.1182/bloodadvances.2017011197. PubMed PMID: 29296824; PubMed Central PMCID: PMC5728102.
The relative utilities of genome-wide, gene panel, and individual gene sequencing in clinical practice.
Kuo FC, Mar BG, Lindsley RC, Lindeman NI.
Blood. 2017 Jul 27;130(4):433-439. doi: 10.1182/blood-2017-03-734533. Review. PubMed PMID: 28600338; PubMed Central PMCID: PMC5813726.